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Observe Intently (1)pentobarbital will lessen the extent or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a reduce in fentanyl plasma concentrations, insufficient efficacy or, possibly, improvement of a